Doublecortin 抗体
Quick Overview for Doublecortin 抗体 (ABIN2719680)
抗原
See all Doublecortin (DCX) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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产品特性
- Homo sapiens doublecortin (DCX), transcript variant 2
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纯化方法
- Purified from mouse ascites fluids by affinity chromatography
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免疫原
- Full length human recombinant protein of human DCX (NP_835365) produced in HEK293T cell.
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亚型
- IgG1
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应用备注
- WB 1:2000, IF 1:100, FLOW 1:100
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说明
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The concentration of the product may vary between diferrent lots.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5-1.0 mg/mL
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缓冲液
- PBS (PH 7.3) containing 1 % BSA, 50 % glycerol and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- Doublecortin (DCX)
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别名
- DCX
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背景
- This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
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分子量
- 40.4 kDa
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基因ID
- 1641
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NCBI登录号
- NM_178152
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HGNC
- 1641
抗原
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